Monday, June 18, 2018

Suffer the Little Children


The Trump administration’s "zero tolerance" immigration policy has created a humanitarian crisis almost unprecedented in the history of our country. Desperate refugee families fleeing potentially life-threatening situations are being further victimized as they try to seek asylum in the United States.  We have witnessed images of crying children being systematically separated from their parents, held in detention centers, not knowing their fate.  How can we stand by as vulnerable children are further traumatized by this practice which can cause irreparable harm to innocents, affecting their intellectual, emotional and even physical health?  Where is our morality and compassion? 

The American Academy of Pediatrics, American College of Physicians and the American Psychiatric Association have all spoken out against this ruthless practice.   Former First Lady Laura Bush has stated that while she understands the need for border security, "This zero-tolerance policy is cruel. It is immoral. And it breaks my heart.  Our government should not be in the business of warehousing children in converted box stores or making plans to place them in tent cities in the desert outside of El Paso.  These images are eerily reminiscent of the Japanese American internment camps of World War II, now considered to have been one of the most shameful episodes in U.S. history."
In my opinion, to do nothing to right this wrong is to be complicit.  Each one of us needs to take action to stop this horrific and inhumane practice.  Call upon your elected officials to put decency above politics.  We can and must find a better solution.


Judith Wolf, MD
Associate Director, WHEP

The Risks of Being Pregnant While Black


Many people may be shocked to learn that the United States has the highest maternal mortality rate in the developed world - a rate that is actually on the rise, driven primarily by mortality in minority women.  According to the Centers for Disease Control and Prevention (CDC), black women are 3-4 times more likely than white women to die from complications during pregnancy and childbirth: 43.5 deaths per 100,000 live births for black women compared to 12.7 deaths per 100,000 live births for white women.   And for every death, more than 100 women experience potentially life-threatening conditions like hemorrhage, pre-eclampsia, venous thromboembolic events and cardiomyopathy.  The question is why. The answer is at once complicated yet distressingly simple – racism. 

Image result for blackmamasmatter, serena williamsPrevious research on racial and ethnic disparities in obstetrics focused on social and biologic/genetic factors and did not examine quality of care.  However, according to a more recent study examining severe maternal morbidity during childbirth in the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project for 2010-2011*, it appears that racial differences in the site of care and delivery contribute to these disparities.  Strikingly, approximately 75% of black women receive care in 25% of all hospitals that provide lower quality of care.  These high and medium black serving hospitals are predominantly urban teaching hospitals in the South with high delivery volumes and higher proportions of Medicaid patients.  Women (of all races) who delivered in these hospitals had higher rates of severe morbidity compared to low black-serving hospitals, but black women had the highest rates. 

The Black Mammas Matter Alliance (BMMA) has called attention to racism in healthcare, including the experience of celebrities like Serena Williams whose complaints of shortness of breath post-delivery were initially dismissed.  She was subsequently diagnosed with pulmonary emboli.  Many African American women have experienced similar disrespect, bias and discrimination.  The time for action is now.  The only way health outcomes in our country will improve is for racism in health care to be recognized and rectified. 


* Howell et al.  Black-white differences in severe maternal morbidity and site of care.  Am J Obstet  Gynecol 2016; 214: 122.e1-7.


Judith Wolf, MD                              Associate Director, WHEP

 

Thursday, May 10, 2018

Intermittent fasting: a weight loss solution for busy physicians?


 

I noticed this year’s Medscape Physician Lifestyle & Happiness Report (2018) included information regarding which physicians wanted to lose weight (47% of physicians surveyed expressed that they want to lose weight), whether more women or men wanted to lose weight (52% of women physicians versus 45% of men physicians wanted to lose weight), and the percentage of physicians who exercised regularly (35% of physicians reported they exercised 2-3 times a week). This got me thinking about how it might be challenging for busy physicians, to make time for exercise and healthy eating. It wouldn’t be far-fetched to imagine a scenario in which a physician gained a few pounds during a particularly busy period in life, while juggling her career, marriage, and children, all while trying to nurture healthy habits.  

 

Not too long after I read that Medscape report, I came across the concept of intermittent fasting. “Fasting” can mean many things to many people. The word fasting initially conjured up thoughts of painstaking and unpleasant self-deprivation, and it didn’t sound healthy. Some anorexics have been known to describe their non-eating behaviors as “fasting.” Yet, on the other hand, my pious and trim maternal grandmother has fasted every Tuesday for the last 40 years. For her, fasting on Tuesdays is eating only fruit and drinking water before the sun comes up and then abstaining from eating and drinking until the sun goes down again. Similar to the Catholic concept of giving up something for Lent, this once a week fasting exercise helps my grandmother connect with her spirituality and bring herself into a spirit of mindfulness, gratefulness and prayer, while acknowledging all her blessings. I didn’t have negative associations with this type of religious fasting. Rather, I’ve always respected my grandmother’s discipline. Then there is my dad, a busy internist with so many patients per day that, quite often, he simply doesn’t have enough time to eat multiple meals. However, he generally touts going through the day without eating much as something he’s proud of because it helps him limit his caloric intake and maintain his weight. With all these associations swimming around in my head regarding fasting, I was intrigued, and since I was trying to lose a few pounds before my wedding, my curiosity compelled me to, at least, do my own research about intermittent fasting. Was there something to fasting after all?

 

Intermittent Fasting

Intermittent fasting is the concept of fasting for 14 to 16 hours and eating during the remaining 10 or 8 hours (14:10 or 16:8). The goal is to help people consume less calories while optimizing some hormones related to weight control. In addition to the above strategies, there are other ways to do intermittent fasting: the Eat-stop-eat method (do one or two 24 hour fasts per week, i.e. not eating from dinner one night until dinner the following night, aka eating one meal a day); and the 5:2 diet (only eat 500-600 calories on two days a week, but eat normally the other 5 days). As long as people don’t eat much more than usual during meals, when it’s a feeding time, these strategies should help people reduce daily caloric intake, resulting in reduced belly fat and overall weight loss.

 

Intermittent Fasting affects hormones and may hasten fat burn and weight loss

Fasting has consequences on the hormonal state of the body. The main hormones affected by fasting are insulin, human growth hormone (HGH) and Norepinephrine.

Fasting causes insulin to decrease (eating increases insulin) and lower levels of insulin facilitate fat burning.  HGH may have up to a five-fold increase with fasting; among other things, growth hormone aids in fat loss and muscle gain. The nervous system releases norepinephrine during a fast, and this hormone causes body fat to break down into free fatty acids that can be burned for energy. Although, recently, some dieticians popularized the weight loss benefits of eating 5-6 small meals to “keep the metabolism revved up,” fasting for relatively short periods of time may actually increase fat burn. However, fasting for long periods of time (over 48 hours) can suppress metabolism. This idea may have led to the popularization of the concept of not eating too few calories (or consuming below your BMR) lest you go into “starvation mode,” which really doesn’t happen unless you fast for over 48 hours.

 

Intermittent fasting makes caloric restriction easier

Eating fewer calories than you burn has been a proven strategy for weight-loss. Many studies have found that on average, diet has more of an impact on weight-loss than exercise. Sticking to a low calorie diet is easier said than done because it requires calorie counting. With intermittent fasting, the weight loss does not require calorie counting because the feeding timings mediate an overall reduction in caloric intake, naturally, by skipping meals during the fasting times. In addition to the short-term hormonal changes propagated by intermittent fasting, people on this plan lose weight because they are eating less calories per day. A 2014 review by Barnosky et al. found that intermittent fasting reduced body weight by 3-8% over a period of 3 to 24 weeks. People lost about 0.55 pounds per week with intermittent fasting. The subjects also lost 4-7 % of their waist circumference, suggesting that they lost belly fat. These results show that intermittent fasting can be a useful weight loss tool.

 

Intermittent fasting helps maintain muscle tone

One of the negative consequences of dieting is that it might lead to decreased muscle mass along with decreased fat. A 2011 review by K.A. Varady found that intermittent calorie restriction (as in intermittent fasting) led to the same amount of weight loss as continuous caloric restriction (a traditional diet), but with less loss in muscle mass.

 

My Conclusions

Reading all this about intermittent fasting certainly sounded compelling, so much so, that I decided to try it for myself. It’s only been a week so far, but it has not been too difficult. It’s much easier than counting calories, grams of carbs, or grams of protein. Since I am also strength training these days, I was eager to find an eating plan that may help me maintain muscle mass while still restricting overall calories for my weight loss goals, and, preferably, one that did not force me to eat a crazy protein to carbs ratio. Intermittent fasting works for me so far!

 

Is this a weight loss solution for busy physicians?

It sounds quite likely that it would be effective. In fact, it seems like my dad was doing intermittent fasting all along all these years when he would eat a late “lunch,” at 3 pm, consisting of a danish from a box of pastries that one of the nurses brought in and one banana, which he grabbed from a conference, followed by a well-balanced home-cooked dinner in front of the TV late in the evening. He would have only been eating from 3pm to 11pm (8 hours). While it’s not for everyone, because of its customizability, intermittent fasting does sound like a convenient eating plan for anyone with a busy schedule, physicians and patients alike!

Meghana Agni
DUCOM 2018

 

For more information about Intermittent Fasting, visit Intermittent Fasting 101 — The Ultimate Beginner's Guide:


https://www.healthline.com/nutrition/intermittent-fasting-guide

 
Sources:

Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Translational Research. 2014;164:302-311.

Gunnars Kris. How intermittent fasting can help you lose weight. Authority Nutrition on Healthline. https://www.healthline.com/nutrition/intermittent-fasting-and-weight-loss. June 4, 2017. Accessed April 17, 2018.

Santos HO, Macedo RCO. Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss. Clinical Nutrition ESPEN. 2018;24:14-21.

Peckham, Carol. Medscape Physician Lifestyle & Happiness Report 2018. Medscape. https://www.medscape.com/slideshow/2018-lifestyle-happiness-6009320#20. January 10, 2018. Accessed April 17, 2018.


Persynaki A, R.D, Karras, Spyridon, M.D., Ph.D, Pichard, Claude, M.D., Ph.D. Unraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review. Nutrition. 2016;2017;35:14-20.

Varady KA. Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Obesity Reviews. 2011;12:e593-e601.

 

 

Thursday, April 26, 2018

Bone Health: Beyond sticks and stones…


As the month of May is upon us, it seems fitting to write this blog about a condition May is dedicated to. May is National Osteoporosis awareness and prevention month. According to the US Surgeon General’s 2004 report Bone Health and Osteoporosis: A Report of the Surgeon General, the number of hip fractures in the US may double or the numbers may be much worse by 2020. This seems to be due not only to the increase in longevity of the population, but also the lack of emphasis on bone health in the past.

The Numbers

About 10 million of Americans have osteoporosis and 44 million are at risk of osteoporosis due to low bone density. An estimated 2 million broken bones per year are due to osteoporosis with 1 in 2 women over 50 having fractures due to osteoporosis. Yet about 80% of elderly Americans suffering from bone fractures are not tested for osteoporosis.

Why should we care about osteoporosis?

Well a risk of fracture in a woman is equal to the risk of breast, uterine and ovarian cancer combined!! The risk of breast cancer alone is 1 in 8 or 12.5%.

What is the severity of these fractures?

About a quarter of patients over 50 who have hip fractures end up dying within the following year. Of nearly 300,000 hip fracture patients that survive hip fractures, a quarter end up in nursing homes, and half never regain their previous abilities and function
Defining osteoporosis.

Osteoporosis is a systemic disease involving the skeleton characterized by low bone mass, weakening of the composites of bone tissue causing the bone to become fragile and susceptible to fractures.

Osteoporosis is defined as a bone mineral density that is 2.5 standard deviations or more below the young woman (t-score -2.5 or below)




 
Bones are part of the skeleton which is an active organ. Bones have 2 functions: storage of certain minerals such as calcium and provide structure for the body. Whenever the body runs low in these minerals (mainly calcium), bone is broken down to release calcium into the blood stream. If calcium is too low and too much of the stored calcium is released, bone can become brittle and break.
Risks and causes of osteoporosis.

Risk factors that can’t be changed

  • Older age, female gender, menopause, family history, small/thin body type, broken bones/height loss

Risk factors that are controllable

  • Diet: calcium and vitamin D intake
    • Recommended daily intake of calcium and vitamin D.
  • Diet: fruits and vegetables
  • Lack of exercise
  • High alcohol consumption- more than 2 beverages a day is considered heavy consumption. Moderate consumption may improve bone strength in postmenopausal women.
  • Diet: rapid weight reduction causes bone loss
  • Smoking

Causes of osteoporosis


  • Many conditions also cause bone loss including
    • Inflammatory bowel disease
    • Pancreatic disease
    • Celiac disease
    • Bariatric (weight loss) surgery)
    • Blood diseases such as sickle cell anemia
    • Lupus and others
    • Epilepsy
    • Stroke
    • HIV
  • Lifestyle
    • Vitamin D insufficiency
    • Smoking
    • Low calcium intake
    • Low physical activity
    • High phosphate intake
    • High salt intake
    • Excess vitamin A
    • Excess protein intake
    • Alcohol abuse
  • Medications that can decrease bone density
    • Androgen blockers (Lupron)
    • Anticonvulsants (Dilantin, phenobarbital)
    • Anticoagulants (heparin)
    • Cancer chemotherapy (Cyclosporine A, Tacrolimus, Methotrexate)
    • Estrogen blockers (Tamoxifen)
    • Steroids (cortisone, prednisone)
    • Contraceptives (Depo-Provera)
    • Thyroid replacement hormones (excess)



Let’s break the barrier to bone health by increasing awareness and preventing osteoporosis!

The US preventive Services Task Force in 2011 recommended all women age 65 and older to be screened with a type of X-ray called DEXA (dual energy X-ray absorptiometry) scan to prevent osteoporotic fractures. In 2011, women younger than 65 were not mandated to be screened. But the North American Menopause Society 2014 meeting revealed that the USPSTF guidelines caused many missed 75% of women aged between 50-64 with osteoporosis. However, in December of 2017, the USPTF reviewed these recommendations and added that postmenopausal women younger than 65 who are at risk of osteoporosis, determined by formal clinical risk assessment should also be screened for osteoporosis. The new recommendations are still under review and are being updated.

The National Osteoporosis Foundation recommends 5 steps. Focus on these steps even if you are young!



Focus on strengthening your bones, because after all it turns out sticks and stones are not the only threat to their health!!

Christel Francois
DUCOM 2018


References

Chapurlat R D et al: Osteporosis. In : Jameson JL et al, eds: Endocrinology: Adult and Pediatric. 7thed. Philadelphia, PA: Saunders; 2016: 1184-1213, e6.

Cosman, F., de Beur, S.J., LeBoff, M.S. et al. Osteoporos Int (2014) 25: 2359. https://doi.org/10.1007/s00198-014-2794-2





https://www.medscape.org/viewarticle/461563